Antimicrobial Chemotherapeutic Agents
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The
antibiotics not having good activity against Enterobacteriaceae is____________.
Which
of the following tests is used to determine the minimal lethal concentration?
a.
Broth dilution test
b.
Agar dilution test
c.
Dilution susceptibility tests
d. All of these
The
mode of action of polymyxin is to____________.
a.
inhibit protein synthesis
b.
inhibit DNA synthesis
c. injury to the
plasma membrane
d.
inhibit folic acid synthesis
Which
of the following drugs may show plasmid-mediated resistance?
a.
Nalidixic acid
b. Ampicillin
c.
Rifampicin
d.
Methicillin
The
scientist who first discovered the substance penicillin was____________.
a.
Joseph Lister
b. Alexander Fleming
c.
Paul Ehrlich
d.
none of these
More
promising chemotherapeutic agents for treating viral diseases is____________.
a.
leukocytic interferon
b.
fibroblast interferon
c. interferon
d.
nystatin
A
parenteral route of drug administration refers to____________.
a.
oral
b. nonoral
c.
intravenously
d.
intramuscularly
By
which of the following means antifungal chemotherapeutic agents may affect
fungi?
a.
Interfere with nuclear division by preventing the aggregation of microtubules
needed for mitosis
b.
Interfere with normal nucleic acid synthesis
c.
Interfere with ergosterol biosynthesis and thus alter the structure of the
cytoplasmic membrane as well as the function of several membrane-bound enzymes
like those involved in nutrient transport and chitin synthesis
d. all of these
Which
of the following methods would be most appropriate for sterilizing an
antibiotic solution?
a.
Dry heat sterilization
b. Microfiltration
c.
Autoclaving
d.
Desiccation
Which
of the following drugs involves modification of the drug by enzymatic
modification or degradation of its active element to alter its/their
resistance?
a.
Pencillins
b.
Choloramphenicol
c.
Aminoglyosides
d. All of these
Who
developed the concept of specific toxicity?
a.
Pasteur
b.
Fleming
c.
Watson
d. Ehrlich
Which
of the following is a drug that interferes with the process of DNA production
in the virus that causes genital herpes?
a.
Erythromycin
b.
Vancomycin
c.
Amantadine
d. Acyclovir
Which
of the antibiotic is not used as a food preservative ?
a.
Pimaricin
b.
Nisin
c.
Tylosin
d. β-lactam
antibiotic
When
using alcohol as an antiseptic, which concentration is considered most
effective?
a.
95%
b.
50%
c. 70%
d.
25%
Fluoroquinolones
are antibiotics which inhibit____________.
a.
DNA polymerase
b.
RNA polymerase
c. DNA gyrase
d.
Cross-linking of peptidoglycan
Which
of the following is used only in life-threatening situations when no other drug
is adequate?
a.
Penicillin
b.
Tetracycline
c. Chloramphenicol
d.
Streptomycin
The
susceptibility of a microorganism to antibiotics and other chemotherapeutic
agents can be determined by using____________.
a.
tube dilution technique
b.
paper disk plate
c. both (a) and (b)
d.
none of these
Most
antibiotics are isolated from____________.
a.
viruses
b.
aquatic microorganisms
c. soil
microorganisms
d.
plants
The
most selective antibiotics are those that interfere with the synthesis of____________.
a.
bacterial DNA
b.
bacterial RNA
c. bacterial cell
walls
d.
bacterial plasma membrane
Novobiocin
can be used against____________.
a.
gram +ve Staphylococci
b.
gram -ve Meningococci & Gonococci
c.
Haemophilus
d. all of these
Interference
mechanism of ciprofloxacin and norfloxacin is due to their action on____________.
a.
cell wall synthesis
b.
cell membrane function
c. DNA function
d.
protein synthesis
Cycloserine
inhibits____________.
a.
alanine racemase
b.
D-alanyl - D-alanine synthetase
c. Both (a) and (b)
d.
amidase
Which
of the following group is not the carbohydrate containing antibiotic?
a.
Streptomycin & Streptothricin
b.
Vancomycin & Moenomycin
c.
Everninomycin & Nogirimycin
d. Erythromycin &
candicidin
The
penicillin stable in gastric acid and suitable for oral administration is____________.
a.
methicillin
b.
carbenicillin
c. closacillin
d.
pencillin-G
Which
of the following is not an example of potent antitumer agents?
a.
Anthramycin
b.
Sibromycin
c.
Neothramycin
d. Erythromycin
Which
of the following antibiotics can't be used for treatment of infections with
β-lactamase-producing Staphylococcus aureus?
a.
Vancomycin
b.
Ampicillin/sulbactam
c.
Cephalothin
d. Piperacillin
Which
of the following is not an aminoglycoside antibiotic?
a.
Streptomycin
b.
Neomycin
c.
Kanamycin
d. Cephalosporin
Which
of the following protein synthesis mechanisms may be affected by particular
drugs?
a.
Peptide bond formation
b.
mRNA translocation
c.
Aminoacyl-tRNA binding