Antimicrobial Chemotherapeutic Agents
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a. clindamycin
b.
cefoxitin
c.
trimethoprim-sulphamethoxazole
d.
ciprofloxacin
The
nitrofurans differ from the antibiotics in that they____________.
a. do not occur
naturally
b.
occur naturally
c.
are antimicrobial drugs
d.
all of these
Quinolones
are____________.
a.
antimetabolites
b.
penicillin derivatives
c.
bacteriostatic
d. broad-spectrum
Which
is not an amino acid and peptide antibiotic?
a.
Penicillin
b.
Actinomycin
c.
Bacitracin
d. Tetranactin
Cephalosporins
and Penicillins interfere with which of the following?
a.
Protein synthesis
b.
DNA function
c.
Cell membrane function
d. Cell wall
synthesis
Which
of the following is not a semi synthetic chemotherapeutic agent?
a.
Ampicillin
b.
Carbenicillin
c. Penicillin
d.
Sulfonamide
The
compound(s) which act(s) as metabolic antagonist is/are____________.
a.
trimethoprim
b.
sulphonamides
c. both (a) and (b)
d.
none of these
Amphotericin
B and polymyxin interfere with____________.
a.
cell wall synthesis
b.
protein synthesis
c. cell membrane
function
d.
DNA function
Which
antibiotic has a beta-lactam ring?
a.
Cephalosporin
b. Penicillin
c.
Tetracycline
d.
Streptomycin
Chemotherapeutic
agents must____________.
a.
prevent/destroy the activity of a parasite
b.
leave unaltered the host's natural defense mechanisms
c.
be able to come in contact with the parasite by penetrating the cells
d. all of the above
Polyene
antibiotics are____________.
a. large ring
structures
b.
β-lactam - thiazolidine ring
c.
small ring structures
d.
any of these
Which
of the following may cause resistance to penicillin?
a.
Impermeability of cell envelope
b.
Production of β-lactamases by bacteria
c.
Alteration or lack of penicillin-binding proteins
d. All of the above
The
third generation cephalosporin agents is____________.
a. cefotaxime
b.
cefoxitin
c.
cephalothin
d.
cephalexin
The
penicillin resistant to β-lactamases is____________.
a.
carbenicillin
b. closacillin
c.
penicillin-G
d.
ampicillin
The
antibiotics not clinically useful for Pseudomonas aeruginosa infection is____________.
a.
aminoglycosides
b.
ceftazidime
c.
piperacillin
d. trimethoprim-sulphamethoxazole
The
larger the__________, the better the chemotherapeutic agent.
a. therapeutic index
b.
therapeutic dose
c.
selective toxicity
d.
spectrum
Which
of the following is not β-lactamase-resistant penicillin?
a.
Oxacillin
b.
Nafcillin
c. Carbenicillin
d.
Methicillin
The
antibiotics which affords a broad spectrum of antimicrobial coverage against
aerobic and anaerobic bacteria, rickettsiae, chlamydiae, and mycoplasmas is____________.
a.
gentamicin
b. tetracycline
c.
metronidazole
d.
vancomycin
Chelate
forming peptide antibiotic are/is____________.
a.
bleomycins
b.
sideromycins
c. both (a) and (b)
d.
vancomycin
With
which of the following aminoglycosides interfere?
a. Protein synthesis
b.
DNA function
c.
Cell wall synthesis
d.
Cell membrane function
Quinones
and related antibiotics are____________.
a.
tetracyclines
b.
actinorhodin
c.
mitomycin
d. all of these
Both
penicillin and fluoroquinolones____________.
a. bind to and
inactivate a bacterial protein
b.
inhibit the cross-linking of peptidoglycan
c.
are inactivated by β-lactamase
d.
must be transported into the cytoplasm in order to act
A
broad-spectrum antibiotic such as chloramphenicol is one that____________.
a.
kills both Gram positive and Gram negative bacteria
b.
kills all bacteria
c. kills numerous
types of microbes
d.
kills all microorganisms
Vancomycin
inhibits peptidoglycan synthesis by binding____________.
a. D-alanyl -
D-alanine
b.
alanine racemase
c.
D-alanyl - D-alanine synthetase
d.
amidase
Nystatin
is a drug used for treatment of diseases caused by____________.
a.
gram negative bacterium
b.
gram positive bacterium
c. yeast
d.
protozoan
Bacterial
cells susceptible to penicillium can be protected from destruction if the
medium in which they are exposed is of____________.
a. high osmotic
pressure
b.
low osmotic pressure
c.
moderate osmotic pressure