Immune System
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Natural killer
cells are involved in__________
a. Tumour
rejection
b. Allograft
rejection
c. Non-specific
killing of virus transformed target cells
d. All of these
Which of the
following(s) is/are the determinants of antigenicity?
a. Chemical
nature
b. Size of
the antigen
c. Foreignness
d. All of these
Which of the
following is correct?
a. All T
Cells are CD4+
b. An
epitope can have multiple antigens
c. T Cell receptors are generated by
random assortment of gene cassettes
d. MHC
Class II molecules are generated by random assortment of gene cassettes
Polymorphonuclear
leukocytes (or PMNs) __________
a. Can be
attracted to the site of an infection following activation of complement
b. Are
derived from bone marrow stem cells
c. Are a
type of phagocyte that can engulf and kill bacteria
d. All of the above
Major Histo
Compatibility Complex (MHC) is a collection of genes arrayed on__________
a. Chromosome
21 in man, chromosome 6 in mice
b. Chromosome
6 in man, chromosone 21 in mice
c. Chromosome
17in man, chromosome 6 in mice
d. Chromosome 6 in man, chromosome
17 in mice
CD8 surface antigen
is present in__________
a. Cytotoxic
T cells
b. Suppresssor
T cells
c. Both (a) and (b)
d. None of
these
Treatment with
bacterial endotoxins results blast formation in__________
a. B cells
b. T cells
c. Monocytes
d. None of
these
Which of the
following is correct for isoantigens?
a. They are
antigens found in all members of different species
b. They are antigens found in some
members of a species
c. They are
antigens found in all members of a species
d. They are
antigens found in some members of different species
Numerous antibodies
can be prepared, against one antigen, each binds to unique epitopes. How is
this antibody diversity generated?
a. By
rearrangements of the DNA encoding the variable regions of the heavy and light chains
b. By the
combination of different heavy and light chains that form the antigen binding
site
c. Antibody
proteins can physically change their shape to bind different epitopes
d. Both (a) and (b)
Which of the
following expresses CD3 surface antigen?
a. Granulocytes
b. T cells
c. Monocytes
d. B cells
Large parasites
such as helminthes may be killed extracellularly by the action of__________
a. Basophils
b. Monocytes
c. Eosinophils
d. Neutrophils
Which of the
following is correct for CD8 T cells?
a. CD8 T
cells only recognize virus-infected cells
b. CD8 T
cell receptor recognizes epitopes that are also commonly recognized by B cells
c. In the
thymus, CD8 T cells undergo positive selection only, whereas CD4 T cells
undergo negative selection only
d. CD8 T cells can kill individual
virus-infected cells in a contact dependent fashion
Passive
immunization is done for__________
a. Tuberculosis
b. Diphtheria
c. Enteric
fever
d. All of
these
Chemically an
antigen may be__________
a. Lipid
b. Proteinc
c. Polysaccharide
d. Any of these
T cell receptors
(or TCR ) on CD4+ T cells__________
a. Recognize
peptides not associated with MHC molecules
b. Recognize
peptides associated with MHC class I molecules
c. Recognize peptides associated
with MHC class II molecules
d. Are
secreted out into the environment to bind antigens
Which of the
following proteins would not need localization signal?
a. A
nuclear protein
b. A cytosolic protein
c. A
protein bound to the endoplasmic reticulum (ER) membrane
d. A cell
surface protein
Following are the
defenses of the colon except__________
a. sIgA
b. Fast flow rate
c. Dense
resident microbiota
d. Mucus
Immunity is not
long lasting to__________
a. Influenza
b. Whooping
cough
c. Diphtheria
d. Mumps
Lysozyme is present
in__________
a. Sweat
b. Cerebro
spinal fluid (CSF)
c. Urine
d. Saliva
Macrophages are
professional antigen- presenting cells. The protein molecule through which they
present antigen in human is__________
a. Actin
b. Interleukin
c. HLA
d. CD8
The role of the M
cell is to__________
a. Trap
virus in mucus and prevent entry
b. Induce
apoptosis in virus-infected small intestinal epithelia cells
c. Pass bacteria or virus to underlying
macrophages for processing and presentation of antigen
d. They use
their cilia to propel mucus out of the small intestine
Which of the
following statements is false regarding B cells?
a. B cells
can undergo class switching and produce a different antibody type
b. B one marrow stem cells migrate
to the thymus and develop into B cells
c. B cells
synthesize antibodies and put them on their cell surface
d. B cells
that recognize high concentrations of antigens (self) in the absence of other
signals undergo apoptosis in the bone marrow
Cytotoxic T-cells
can be recognized by which of the following cell surface marker?
a. CD4
b. CD7
c. CD8
d. CD9
Which is not an
antigen-presenting cell (or APC)?
a. B cell
b. Polymorphonuclear leukocyte (or
PMN)
c. Dendritic
cell
d. All of
the above